Hnrnph1 Gene Summary [Mouse]
Predicted to enable RNA binding activity; enzyme binding activity; and identical protein binding activity. Acts upstream of or within cellular response to interleukin-7. Predicted to be located in cytosol and nucleus. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleoplasm and postsynaptic density. Is expressed in several structures, including brain; gut; liver; olfactory epithelium; and respiratory system. Human ortholog(s) of this gene implicated in Sjogren's syndrome. Orthologous to human HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hnrnph1 |
| Official Name | heterogeneous nuclear ribonucleoprotein H1 [Source:MGI Symbol;Acc:MGI:1891925] |
| Ensembl ID | ENSMUSG00000007850 |
| Bio databases IDs | |
| Aliases | heterogeneous nuclear ribonucleoprotein H1 |
| Synonyms | AC270306.4, AI642080, E430005G16Rik, heterogeneous nuclear ribonucleoprotein H1, Hnrh1, hnRNP H, HNRPH, HNRPH1, NEDCDS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hnrnph1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- low complexity domain
- RNA recognition motif
- enzyme binding
- protein binding
- identical protein binding
- RNPHF zinc finger
- RNA binding
- poly(U) binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- hereditary disorder
- neoplasia
- survival
- neurodevelopmental disorder with craniofacial dysmorphism and skeletal defects
- conventional mantle cell lymphoma
- Bain type X-linked syndromic mental retardation
- head and neck cancer
- Duke stage B2 colon carcinoma
- colon epithelial cancer
role in cell
- apoptosis
- expression in
- decitabine sensitivity
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- cytosol
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- nucleoli
- chromatin
- postsynaptic density
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hnrnph1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of RNA splicing
- RNA processing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- poly(U) RNA binding