Fhod1 Gene Summary [Mouse]
Predicted to enable actin filament binding activity and identical protein binding activity. Acts upstream of or within establishment of centrosome localization and nuclear migration. Located in intercalated disc. Is expressed in several structures, including gut; metanephros; nervous system; respiratory system; and sensory organ. Orthologous to human FHOD1 (formin homology 2 domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Fhod1 |
| Official Name | formin homology 2 domain containing 1 [Source:MGI Symbol;Acc:MGI:2679008] |
| Ensembl ID | ENSMUSG00000014778 |
| Bio databases IDs | |
| Aliases | formin homology 2 domain containing 1 |
| Synonyms | FHOS, FHOS1, formin homology 2 domain containing 1, LOC234686 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fhod1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase binding domain
- formin homology domain 1
- Formin Homology 2 Domain
- PXsP motif
- Diaphanous inhibitory domain
- diaphanous autoregulatory domain
- protein binding
- Formin N-terminal GTPase-binding domain
- identical protein binding
- Serine Proline motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- glioblastoma
- glioblastoma cancer
- organismal death
- overall survival
role in cell
- proliferation
- growth
- phosphorylation in
- expression in
- migration
- formation
- organization
- invasion by
- quantity
- orientation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- intercellular junctions
- cytosol
- nucleoplasm
- actin stress fibers
- light microsome fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fhod1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cortical actin cytoskeleton organization
- establishment of centrosome localization
- positive regulation of stress fiber assembly
- nuclear migration
- regulation of stress fiber assembly
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- stress fiber
- membrane
- bleb
- cytosol
- intercalated disc
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- identical protein binding
- protein binding