Myl2 Gene Summary [Mouse]
Predicted to enable actin monomer binding activity and calcium ion binding activity. Predicted to be a structural constituent of muscle. Involved in heart contraction; heart development; and positive regulation of the force of heart contraction. Acts upstream of or within several processes, including cardiac muscle contraction; heart development; and muscle cell fate specification. Located in myofibril. Is expressed in several structures, including aorta; embryo mesoderm; eye; heart; and triceps surae muscle. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy 10; and infantile-onset myofibrillar myopathy 12 with cardiomyopathy. Orthologous to human MYL2 (myosin light chain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myl2 |
| Official Name | myosin, light polypeptide 2, regulatory, cardiac, slow [Source:MGI Symbol;Acc:MGI:97272] |
| Ensembl ID | ENSMUSG00000013936 |
| Bio databases IDs | |
| Aliases | myosin, light polypeptide 2, regulatory, cardiac, slow |
| Synonyms | Beta ml2v, CMH10, Crlc, Gm32672, MFM12, MLC-2, MLC-2s/v, MLC-2v, Mlv2v, MRLC, MRLC2, Mylc2, Mylpc, Myosin II light-chain, Myosin light chain 1, slow twitch/ ventricular, myosin light chain 2, myosin, light polypeptide 2, regulatory, cardiac, slow, Myosin Regulatory Light Chain2 Ventricular Isoform, myosin ventricular regulatory light chain, myosin vRLC, SKELETAL MUSCLE MYOSIN P-LIGHT CHAIN, β ml2v |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- structural constituent of muscle
- actin monomer binding
- EF hand
- EF-hand domain pair
- calcium ion binding
- EFh
- protein binding
- phosphorylation site
Pathways
Biological processes and signaling networks where the Myl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Calcium Signaling
- Cardiomyocyte Differentiation via BMP Receptors
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chemokine Signaling
- CXCR4 Signaling
- Ephrin A Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- PAK Signaling
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Serotonin Receptor Signaling
- Thrombin Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- insulin-dependent diabetes mellitus
- COVID-19
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- primary dilated cardiomyopathy
- dilated cardiomyopathy
- familial hypertrophic cardiomyopathy-10
- coronary artery disease
- dilated cardiomyopathy 1S
role in cell
- formation
- growth
- quantity
- differentiation
- development
- fragmentation
- stiffening
- assembly
- morphology
- fragmentation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- constriction sites
- cytoskeleton
- cellular membrane
- actin cytoskeleton
- cell cortex
- sarcomere
- cytosol
- apical membrane
- plasma membrane projections
- myofibrils
- actin stress fibers
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of the force of heart contraction
- heart development
- heart contraction
- ventricular cardiac muscle tissue morphogenesis
- negative regulation of cell growth
- muscle cell fate specification
- cardiac myofibril assembly
- cardiac muscle contraction
- regulation of striated muscle contraction
Cellular Component
Where in the cell the gene product is active
- myosin complex
- cytoskeleton
- cytoplasm
- actin cytoskeleton
- cytosol
- A band
- sarcomere
- myofibril
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of muscle
- calcium ion binding
- myosin heavy chain binding
- actin monomer binding