Dbndd2 Gene Summary [Mouse]
Enables ATPase binding activity. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; monoatomic ion homeostasis; and neuron projection development. Is active in endoplasmic reticulum and lysosome. Is expressed in genital tubercle and urethral plate. Orthologous to human DBNDD2 (dysbindin domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dbndd2 |
| Official Name | dysbindin (dystrobrevin binding protein 1) domain containing 2 [Source:MGI Symbol;Acc:MGI:106562] |
| Ensembl ID | ENSMUSG00000017734 |
| Bio databases IDs | |
| Aliases | dysbindin (dystrobrevin binding protein 1) domain containing 2 |
| Synonyms | 1110017A21Rik, 2900022J10Rik, C20orf35, CK1BP, D2Bwg0891e, dysbindin domain containing 2, HSMNP1, Nkip, R74724, RGD1311642 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dbndd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- Dysbindin (Dystrobrevin binding protein 1)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- cancer
- epithelial cancer
- liver cancer
- preeclampsia
- glioblastoma
- glioblastoma cancer
- cholangiocarcinoma cancer
- bile duct cancer
- liver neoplasia
regulates
- ion
role in cell
- apoptosis
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
- Endoplasmic Reticulum
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dbndd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein kinase activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding