Calcoco2 Gene Summary [Mouse]
Predicted to enable protein homodimerization activity. Predicted to be involved in positive regulation of autophagosome maturation; response to type II interferon; and xenophagy. Predicted to be located in cytosol; intracellular membrane-bounded organelle; and perinuclear region of cytoplasm. Predicted to be active in PML body and autophagosome. Orthologous to human CALCOCO2 (calcium binding and coiled-coil domain 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Calcoco2 |
| Official Name | calcium binding and coiled-coil domain 2 [Source:MGI Symbol;Acc:MGI:1343177] |
| Ensembl ID | ENSMUSG00000006056 |
| Bio databases IDs | |
| Aliases | calcium binding and coiled-coil domain 2 |
| Synonyms | 2410154J16Rik, calcium binding and coiled-coil domain 2, NDP52, NDP52L1, NUCLEAR domain 10 protein 52, RGD1559974 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Calcoco2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBZ domain
- SKICH domain
- Modifier of rudimentary (Mod(r)) protein
- Tropomyosin like
- Zn-C2H2_CALCOCO1_TAX1BP1_like
- Growth-arrest specific micro-tubule binding
- protein homodimerization
- protein binding
- Autophagy receptor zinc finger-C2H2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- mucoepidermoid carcinoma
- serous ovarian adenocarcinoma
- serous ovarian cancer
role in cell
- degradation in
- proliferation
- apoptosis
- maturation
- proliferation in
- autophagy
- autophagy by
- autophagy in
- degradation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- cytosol
- autophagic vacuoles
- PML nuclear bodies
- cytoskeletal fraction
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Calcoco2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to interferon-gamma
- viral reproduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoskeleton
- PML body
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- cytoplasmic vesicle
- autophagic vacuole
- autophagic vacuole membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- metal ion binding