Csnk1e Gene Summary [Mouse]

The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Details

Type
Protein Coding
Official Symbol
Csnk1e
Official Name
casein kinase 1, epsilon [Source:MGI Symbol;Acc:MGI:1351660]
Ensembl ID
ENSMUSG00000022433
Bio databases IDs NCBI: 27373 Ensembl: ENSMUSG00000022433
Aliases casein kinase 1, epsilon
Synonyms AI426939, AI551861, AW457082, casein kinase 1 epsilon, casein kinase 1, epsilon, casein kinase 1 ε, casein kinase 1, ε, CK1epsilon, Ck1 ε, CKIe, CKI epsilon, CKI ε, Epsilon casein, HCKIE, KC1epsilon, tau, ε casein
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Csnk1e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • kinase
  • Serine/Threonine protein kinases, catalytic domain
  • kinase domain
  • protein serine/threonine kinase
  • Protein kinase (unclassified specificity)
  • protein kinase
  • Protein Kinases, catalytic domain
  • Protein tyrosine and serine/threonine kinase
  • autophosphorylation site
  • protein binding
  • Tyrosine kinase, catalytic domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • chronic lymphocytic leukemia
  • follicular B-cell or T-cell lymphoma
  • marginal zone cell lymphoma
  • developmental disorder
  • breast cancer
  • refractory mantle cell lymphoma
  • recurrent non-Hodgkin lymphoma
  • relapsed mantle cell lymphoma
  • refractory non Hodgkin lymphoma
  • osteoarthritis
regulated by
regulates
role in cell
  • degradation in
  • proliferation
  • binding in
  • phosphorylation in
  • survival
  • apoptosis
  • growth
  • migration
  • outgrowth
  • translation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • perinuclear region
  • Nucleus
  • cytosol
  • nucleoplasm
  • growth cone
  • actin stress fibers
  • perikaryon

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Csnk1e gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • DNA repair
  • regulation of protein localization
  • signal transduction
  • positive regulation of non-canonical Wnt receptor signaling pathway
  • protein localization
  • positive regulation of canonical Wnt receptor signaling pathway
  • circadian behavior
  • protein phosphorylation
  • endocytosis
  • regulation of circadian rhythm
  • negative regulation of protein binding
  • circadian regulation of gene expression
  • canonical Wnt receptor signaling pathway
  • negative regulation of Wnt receptor signaling pathway
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process
  • peptidyl-serine phosphorylation

Cellular Component

Where in the cell the gene product is active
  • growth cone
  • nucleus
  • cytoplasm
  • cytosol
  • neuronal cell body
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • ATP binding
  • protein binding
  • RNA binding
  • protein kinase activity
  • protein serine/threonine kinase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.