Glra2 Gene Summary [Mouse]
Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in modulation of chemical synaptic transmission. Is active in GABA-ergic synapse; glycinergic synapse; and postsynaptic specialization membrane. Is expressed in brain; spinal cord; and vascular element. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Pilorge type. Orthologous to human GLRA2 (glycine receptor alpha 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Glra2 |
| Official Name | glycine receptor, alpha 2 subunit [Source:MGI Symbol;Acc:MGI:95748] |
| Ensembl ID | ENSMUSG00000018589 |
| Bio databases IDs | |
| Aliases | glycine receptor, alpha 2 subunit |
| Synonyms | GLR, glycine receptor alpha 2, glycine receptor, alpha 2, glycine receptor, alpha 2 subunit, glycine receptor α 2, glycine receptor, α 2, glycine receptor, α 2 subunit, Glyr α 2, LOC100910572, MRXSP, RNNEOGLY |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Glra2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- ion channel
- anion channel
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- glycine binding
- cytoplasmic loop
- Neurotransmitter-gated ion-channel ligand binding domain
- chloride channel
- ligand-gated ion channel
- glycine-gated chloride channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- infection
- hypertrophic obstructive cardiomyopathy
- alcohol use disorder
- septicemia
- X-linked Pilorge type syndromic intellectual developmental disorder
- pancreatic adenocarcinoma
- hypertension
- skin infection
- neutropenia
regulated by
- strychnine
- Zn2+
- glycine
- picrotoxin
- taurine
- beta-alanine
- ethanol
- SNCA
- dexamethasone
- cyclothiazide
regulates
- ELANE
- chloride
- ion
role in cell
- response
- fusion
- response by
- fusion in
- excitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Glra2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to ethanol
- cellular response to amino acid stimulus
- neuropeptide signaling pathway
- regulation of excitatory postsynaptic membrane potential
- regulation of membrane potential
- cellular response to zinc ion
- ion transmembrane transport
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- postsynaptic membrane
- intracellular membrane-bounded organelle
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- extracellular-glycine-gated chloride channel activity
- metal ion binding
- neurotransmitter receptor activity
- excitatory extracellular ligand-gated ion channel activity
- glycine binding
- chloride channel activity
- glycine-gated chloride ion channel activity