Nup35 Gene Summary [Mouse]
Enables identical protein binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nuclear envelope; nucleoplasm; and plasma membrane. Predicted to be part of nuclear pore central transport channel and nuclear pore nuclear basket. Is expressed in cerebellum. Used to study intestinal pseudo-obstruction. Orthologous to human NUP35 (nucleoporin 35). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Nup35 |
| Official Name | nucleoporin 35 [Source:MGI Symbol;Acc:MGI:1916732] |
| Ensembl ID | ENSMUSG00000026999 |
| Bio databases IDs | |
| Aliases | nucleoporin 35 |
| Synonyms | 2310006I24RIK, 5330402E05Rik, AK009187, LOC129401, mitotic phosphoprotein 44, MP-44, NO44, NP44, nucleoporin 35, NUP53 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nup35 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- protein binding
- Nup53/35/40-type RNA recognition motif
- identical protein binding
- transporter
Pathways
Biological processes and signaling networks where the Nup35 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- intracellular membrane-bounded organelle
- Plasma Membrane
- cytosol
- nuclear pores
- nucleoplasm
- nuclear rim
- nuclear envelope
- nuclear lamina
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nup35 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleocytoplasmic transport
- nuclear pore organization
- NLS-bearing substrate import into nucleus
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- cytosol
- plasma membrane
- nucleoplasm
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- identical protein binding
- protein binding
- structural constituent of nuclear pore
- phospholipid binding