Nova1 Gene Summary [Mouse]
Enables mRNA 3'-UTR binding activity and sequence-specific mRNA binding activity. Involved in negative regulation of cold-induced thermogenesis and regulation of alternative mRNA splicing, via spliceosome. Acts upstream of or within mRNA splicing, via spliceosome and regulation of RNA metabolic process. Located in nucleus. Is expressed in several structures, including nervous system and retina. Orthologous to human NOVA1 (NOVA alternative splicing regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nova1 |
| Official Name | NOVA alternative splicing regulator 1 [Source:MGI Symbol;Acc:MGI:104297] |
| Ensembl ID | ENSMUSG00000021047 |
| Bio databases IDs | |
| Aliases | NOVA alternative splicing regulator 1 |
| Synonyms | 9430099M15Rik, G630039L02, NOVA alternative splicing regulator 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nova1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- K homology (KH) RNA-binding domain, type I
- KH domain
- mRNA binding
- protein binding
- K homology RNA-binding domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- organismal death
- ETV6-RUNX1 positive B-lineage acute lymphoblastic leukemia
- pervasive developmental disorder
- astrocytoma
- glioma formation
role in cell
- migration
- proliferation
- apoptosis
- invasion by
- alternative splicing by
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nova1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of alternative nuclear mRNA splicing, via spliceosome
- nervous system development
- RNA processing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding
- mRNA 3'-UTR binding