Tada2a Gene Summary [Mouse]
Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to contribute to histone acetyltransferase activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Acts upstream of or within several processes, including chromatin organization; regulation of protein modification process; and regulation of protein stability. Located in mitotic spindle and nucleus. Part of ATAC complex. Orthologous to human TADA2A (transcriptional adaptor 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tada2a |
| Official Name | transcriptional adaptor 2A [Source:MGI Symbol;Acc:MGI:2144471] |
| Ensembl ID | ENSMUSG00000018651 |
| Bio databases IDs | |
| Aliases | transcriptional adaptor 2A |
| Synonyms | ADA2, ADA2A, ADA2-like, D030022J10Rik, hADA2, KL04P, TADA2L, transcriptional adaptor 2A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tada2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZZ
- SANT
- transcription regulator
- histone acetyltransferase
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- Myb-like DNA-binding domain
- SWIRM domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tada2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell division
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of tubulin deacetylation
- regulation of embryonic development
- regulation of transcription, DNA-dependent
- regulation of cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitotic spindle
- SAGA-type complex
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- histone acetyltransferase activity
- zinc ion binding
- protein binding
- transcription coactivator activity
- chromatin binding