Taf6l Gene Summary [Mouse]
Predicted to enable transcription coactivator activity. Involved in regulation of DNA-templated transcription and regulation of somatic stem cell population maintenance. Located in nucleus. Is expressed in tail. Orthologous to human TAF6L (TATA-box binding protein associated factor 6 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Taf6l |
| Official Name | TATA-box binding protein associated factor 6 like [Source:MGI Symbol;Acc:MGI:2444957] |
| Ensembl ID | ENSMUSG00000003680 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 6 like |
| Synonyms | 2810417N14RIK, C530024J06Rik, PAF65A, TATA-box binding protein associated factor 6 like |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taf6l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- transcription regulator
- transcription co-activator
- TATA box binding protein associated factor (TAF)
- C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)
- protein binding
- TATA box binding protein associated factor
- DNA binding
Pathways
Biological processes and signaling networks where the Taf6l gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taf6l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA polymerase II transcriptional preinitiation complex assembly
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of DNA repair
- regulation of RNA splicing
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- transcription factor TFIID complex
- SLIK (SAGA-like) complex
- histone deacetylase complex
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription coactivator activity
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity