Pdlim7 Gene Summary [Mouse]
Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Acts upstream of or within actin cytoskeleton organization. Located in cytoplasm; ruffle; and stress fiber. Is expressed in several structures, including cardiovascular system; gut; limb primordium; respiratory system; and tooth. Orthologous to human PDLIM7 (PDZ and LIM domain 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Pdlim7 |
| Official Name | PDZ and LIM domain 7 [Source:MGI Symbol;Acc:MGI:1914649] |
| Ensembl ID | ENSMUSG00000021493 |
| Bio databases IDs | |
| Aliases | PDZ and LIM domain 7 |
| Synonyms | 1110003B01RIK, AV007930, Enigma, LMP, LMP1, PDZ and LIM domain 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdlim7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Pdlim7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- papillary thyroid carcinoma
- papillary thyroid cancer
- renal cell carcinoma
- renal cell cancer
role in cell
- apoptosis
- expression in
- differentiation
- migration
- density
- mineralization in
- destabilization in
- organization
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- ruffle
- cell periphery
- focal adhesions
- actin cytoskeleton
- cytosol
- nucleoplasm
- Z line
- transverse tubules
- actin stress fibers
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdlim7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- ossification
- cell differentiation
- muscle structure development
- actin cytoskeleton organization
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- Z disc
- adherens junction
- focal adhesion
- stress fiber
- actin cytoskeleton
- ruffle
- cytosol
- filamentous actin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- metal ion binding
- muscle alpha-actinin binding