Abca5 Gene Summary [Mouse]
Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Involved in several processes, including cholesterol efflux; negative regulation of macrophage derived foam cell differentiation; and regulation of cholesterol transport. Located in late endosome and lysosome. Is expressed in cortical hem. Orthologous to human ABCA5 (ATP binding cassette subfamily A member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abca5 |
| Official Name | ATP-binding cassette, sub-family A (ABC1), member 5 [Source:MGI Symbol;Acc:MGI:2386607] |
| Ensembl ID | ENSMUSG00000018800 |
| Bio databases IDs | |
| Aliases | ATP-binding cassette, sub-family A (ABC1), member 5 |
| Synonyms | ABC13, ATP binding cassette subfamily A member 5, ATP-binding cassette, sub-family A member 5, B930033A02Rik, DEL17q24, EST90625, HTC3, HTGH, mKIAA1888 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abca5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FeS assembly ATPase SufC
- ABC-2 family transporter protein
- phosphonate ABC transporter, ATP-binding protein
- daunorubicin resistance ABC transporter ATP-binding subunit
- nitrate transport ATP-binding subunits C and D
- heme ABC exporter, ATP-binding protein CcmA
- urea ABC transporter, ATP-binding protein UrtE
- lipid transporter
- LPS export ABC transporter ATP-binding protein
- cobalt transport protein ATP-binding subunit
- energy-coupling factor transporter ATPase
- nickel import ATP-binding protein NikE
- ABC transporter
- thiamine ABC transporter, ATP-binding protein
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- tremor
- hypercholesterolemia
- osteoporosis
- colon cancer
- generalized hypertrichosis terminalis
- dilated cardiomyopathy
- visceral vascular congestion
- aldosterone producing adrenocortical adenoma
- adenoma formation
regulates
- lipid
- cholesterol
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- lysosome
- lysosome membrane
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abca5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- transmembrane transport
- reverse cholesterol transport
- high-density lipoprotein particle remodeling
- cholesterol metabolic process
- regulation of cholesterol efflux
- negative regulation of macrophage derived foam cell differentiation
- cholesterol efflux
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- late endosome
- Golgi membrane
- plasma membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of substances
- lipid transporter activity