Asxl3 Gene Summary [Mouse]
Predicted to enable chromatin binding activity and peroxisome proliferator activated receptor binding activity. Predicted to be involved in animal organ morphogenesis; negative regulation of lipid biosynthetic process; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PR-DUB complex. Is expressed in brain; cortical plate; cortical subplate; and heart. Human ortholog(s) of this gene implicated in Bainbridge-Ropers syndrome. Orthologous to human ASXL3 (ASXL transcriptional regulator 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asxl3 |
| Official Name | ASXL transcriptional regulator 3 [Source:MGI Symbol;Acc:MGI:2685175] |
| Ensembl ID | ENSMUSG00000045215 |
| Bio databases IDs | |
| Aliases | ASXL transcriptional regulator 3 |
| Synonyms | ASXL transcriptional regulator 3, BRPS, C230079D11, C230079D11Rik, D430002O22Rik, D930044O18Rik, Gm329, Gm945, KIAA1713, RGD1305869 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Asxl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HB1, ASXL, restriction endonuclease HTH domain
- DEUBAD_NFRKB
- PHD domain of transcriptional enhancer, Asx
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial ovarian cancer
- Bainbridge-Ropers syndrome
- pervasive developmental disorder
- hereditary disorder
- Parkinson disease
- ovarian carcinoma
- insomnia
- asthma
- syndromic mental retardation
- mental retardation
role in cell
- apoptosis
- proliferation
- expression in
- phosphorylation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Asxl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of lipid biosynthetic process
- positive regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- PR-DUB complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- metal ion binding
- chromatin binding
- peroxisome proliferator activated receptor binding