Ppp3r1 Gene Summary [Mouse]
Enables phosphatase binding activity and phosphoprotein phosphatase activity. Involved in postsynaptic modulation of chemical synaptic transmission; regulation of postsynaptic neurotransmitter receptor internalization; and regulation of synaptic vesicle cycle. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; circulatory system development; and myelination in peripheral nervous system. Located in sarcolemma. Part of calcineurin complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Is expressed in brain; heart; jaw skeleton; lung; and tooth. Used to study dilated cardiomyopathy and schizophrenia. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp3r1 |
| Official Name | protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [Source:MGI Symbol;Acc:MGI:107172] |
| Ensembl ID | ENSMUSG00000033953 |
| Bio databases IDs | |
| Aliases | protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) |
| Synonyms | Calcineurin b, Calcineurin B1, CALNB1, CaNB1, CNB, CNB1, CnB short, MCIP1, Pp2b Beta1, PP2B-R, PP2B REGULATORY A subunit alpha1 (BRAIN-SPECIFIC), Pp2b Regulatory B Subunit Beta 1 (Brain-Specific), Pp2b Regulatory B Subunit β 1 (Brain-Specific), protein phosphatase 3 regulatory subunit B, alpha, protein phosphatase 3, regulatory subunit B, alpha, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I), protein phosphatase 3 regulatory subunit B, α, protein phosphatase 3, regulatory subunit B, α, protein phosphatase 3, regulatory subunit B, α isoform (calcineurin B, type I) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp3r1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain pair
- cyclosporin A binding
- enzyme binding
- EFh
- protein domain specific binding
- protein binding
- EFh_MICU
- EFh_PI-PLC
- The penta-EF hand (PEF) family
- EF-hand domain
- protein phosphatase
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- phosphatase
- phosphatase binding
Pathways
Biological processes and signaling networks where the Ppp3r1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Autophagy
- B Cell Receptor Signaling
- Calcium Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Clathrin-mediated Endocytosis Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- fMLP Signaling in Neutrophils
- Gap Junction Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- HIF1α Signaling
- IL-3 Signaling
- Netrin Signaling
- nNOS Signaling in Neurons
- Nur77 Signaling in T Lymphocytes
- Opioid Signaling Pathway
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- mantle cell lymphoma
- refractory chronic lymphocytic leukemia
- COVID-19
- epithelial cancer
- diabetes mellitus
- acute graft-vs-host disease
- breast cancer
- advanced colon adenocarcinoma
- psoriasis
role in cell
- number
- activation in
- proliferation
- apoptosis
- hypertrophy
- quantity
- degranulation
- development
- differentiation
- switching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- Nucleus
- cytosol
- apical cytoplasm
- basal cytoplasm
- apical membrane
- basal membrane
- nucleoplasm
- synapse
- sarcolemma
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp3r1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcineurin-NFAT signaling cascade
- heart development
- myelination in peripheral nervous system
- lung epithelial cell differentiation
- patterning of blood vessels
- protein import into nucleus
- protein dephosphorylation
- positive regulation of calcineurin-NFAT signaling cascade
- epithelial to mesenchymal transition
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- calcineurin complex
- protein serine/threonine phosphatase complex
- sarcolemma
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- cyclosporin A binding
- calmodulin binding
- protein domain specific binding
- protein binding
- calcium-dependent protein serine/threonine phosphatase activity
- calcium ion binding
- calcium-dependent protein serine/threonine phosphatase regulator activity