Plscr3 Gene Summary [Mouse]
Predicted to enable calcium-dependent protein binding activity; metal ion binding activity; and phospholipid scramblase activity. Involved in apoptotic process and cellular response to lipopolysaccharide. Acts upstream of or within cholesterol homeostasis and glucose homeostasis. Located in mitochondrion and nucleus. Is expressed in ductus deferens; lower urinary tract; testis; and thyroid gland. Used to study obesity. Orthologous to human PLSCR3 (phospholipid scramblase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plscr3 |
| Official Name | phospholipid scramblase 3 [Source:MGI Symbol;Acc:MGI:1917560] |
| Ensembl ID | ENSMUSG00000019461 |
| Bio databases IDs | |
| Aliases | phospholipid scramblase 3 |
| Synonyms | 2210403O21Rik, 2610037N06Rik, ESTM3, phospholipid scramblase 3, Pls3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plscr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- phospholipid scramblase
- mercury ion binding
- calcium ion binding
- metal ion binding
- enzyme
- protein binding
- magnesium ion binding
- proline rich domain
- LURP-one-related
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Nucleus
- Mitochondria
- cytosol
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plscr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- regulation of release of cytochrome c from mitochondria
- apoptotic process
- glucose homeostasis
- phospholipid scrambling
- regulation of apoptotic process
- cholesterol homeostasis
- cardiolipin biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- cytosol
- mitochondrial inner membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- protein binding
- lead ion binding
- mercury ion binding
- calcium ion binding
- calcium-dependent protein binding
- SH3 domain binding
- phospholipid scramblase activity