Rnf43 Gene Summary [Mouse]
Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Involved in negative regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; forelimb epidermis; genitourinary system; lung; and submandibular gland primordium. Human ortholog(s) of this gene implicated in endometrial cancer; gastrointestinal system cancer (multiple); irritable bowel syndrome; lung adenocarcinoma; and villous adenoma. Orthologous to human RNF43 (ring finger protein 43). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Rnf43 |
| Official Name | ring finger protein 43 [Source:MGI Symbol;Acc:MGI:2442609] |
| Ensembl ID | ENSMUSG00000034177 |
| Bio databases IDs | |
| Aliases | ring finger protein 43 |
| Synonyms | 4732452J19RIK, RGD1305204, ring finger protein 43, RNF124, SSPCS, URCC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf43 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- frizzled binding
- ubiquitin protein ligase activity
- ectodomain
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- ZNRF-3 Ectodomain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- endometrial carcinoma
- epithelial endometrial cancer
- sessile serrated polyposis cancer syndrome
- liver cancer
- epithelial cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
role in cell
- expression in
- proliferation
- invasion by
- transcription in
- turnover in
- ubiquitination in
- interaction in
- polyubiquitination in
- vemurafenib resistance
- beta-catenin signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf43 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell proliferation
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- Wnt receptor catabolic process
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- frizzled binding
- protein binding
- metal ion binding