Zic1 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including central nervous system development; positive regulation of protein import into nucleus; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within adult walking behavior and central nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; cranium; embryo mesenchyme; metanephros; and visual system. Used to study Dandy-Walker syndrome and Joubert syndrome. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome and craniosynostosis 6. Orthologous to human ZIC1 (Zic family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zic1 |
| Official Name | zinc finger protein of the cerebellum 1 [Source:MGI Symbol;Acc:MGI:106683] |
| Ensembl ID | ENSMUSG00000032368 |
| Bio databases IDs | |
| Aliases | zinc finger protein of the cerebellum 1 |
| Synonyms | BAIDCS, CRS6, ZIC, Zic family member 1, zinc finger protein of the cerebellum 1, ZNF201 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zic1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- Zinc-finger double domain
- zinc finger domain
- Zic proteins zinc finger domain
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- C2H2-type zinc ribbon
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonalcoholic fatty liver disease
- hereditary disorder
- hypoplasia
- structural brain anomalies with impaired intellectual development and craniosynostosis
- metabolic syndrome X
- ataxia
- growth failure
- hypotonia
- gait disturbance
- craniosynostosis type 6
role in cell
- cell cycle progression
- apoptosis
- proliferation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zic1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein import into nucleus
- pattern specification process
- hippocampus development
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- olfactory bulb development
- spinal cord development
- regulation of smoothened signaling pathway
- regulation of transcription from RNA polymerase II promoter
- adult walking behavior
- central nervous system development
- positive regulation of transcription, DNA-dependent
- inner ear morphogenesis
- cell differentiation
- gene expression
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity