Tube1 Gene Summary [Mouse]
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in centrosome. Predicted to be active in cytoplasm and microtubule. Is expressed in several structures, including central nervous system; eye; and palatal shelf. Orthologous to human TUBE1 (tubulin epsilon 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tube1 |
| Official Name | tubulin, epsilon 1 [Source:MGI Symbol;Acc:MGI:1919174] |
| Ensembl ID | ENSMUSG00000019845 |
| Bio databases IDs | |
| Aliases | tubulin, epsilon 1 |
| Synonyms | 2310061K05Rik, AI551343, dJ142L7.2, epsilon TUBULIN, TUBE, tubulin epsilon 1, tubulin, epsilon 1, tubulin ε 1, tubulin, ε 1, ε TUBULIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tube1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tubulin protein family of FtsZ and CetZ-like
- Tubulin C-terminal domain
- structural constituent of cytoskeleton
- Tubulin/FtsZ family, GTPase domain
- protein binding
Pathways
Biological processes and signaling networks where the Tube1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastroesophageal junction adenocarcinoma
- metastatic esophageal adenocarcinoma
- metastatic gastric adenocarcinoma
- locally advanced gastric adenocarcinoma
- gastric adenocarcinoma
- esophageal adenocarcinoma
- cardiovascular disorder
- disorder of coronary artery
- coronary disease
- locally advanced breast cancer
role in cell
- cycling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tube1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome cycle
- microtubule cytoskeleton organization
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- pericentriolar material
- cytoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- GTP binding
- structural constituent of cytoskeleton