Cct5 Gene Summary [Mouse]
Predicted to enable several functions, including G-protein beta-subunit binding activity; beta-tubulin binding activity; and mRNA binding activity. Acts upstream of or within binding activity of sperm to zona pellucida. Located in cell body. Part of chaperonin-containing T-complex. Is expressed in 1st branchial arch mandibular component and mandible primordium. Orthologous to human CCT5 (chaperonin containing TCP1 subunit 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cct5 |
| Official Name | chaperonin containing Tcp1, subunit 5 (epsilon) [Source:MGI Symbol;Acc:MGI:107185] |
| Ensembl ID | ENSMUSG00000022234 |
| Bio databases IDs | |
| Aliases | chaperonin containing Tcp1, subunit 5 (epsilon) |
| Synonyms | CCTE, CCT-epsilon, CCT-ε, cct ε subunit, chaperonin containing TCP1 subunit 5, Chaperonin subunit 5, Chaperonin subunit 5 (epsilon), Chaperonin subunit 5 (ε), HEL-S-69, HSNSP, KIAA0098, mKIAA0098, PNAS-102, Similar to cct epsilon subunit, Similar to cct ε subunit, T-complex protein 1 epsilon, T-complex protein 1 epsilon subunit, T-complex protein 1 ε, T-complex protein 1 ε subunit, TCP-1-epsilon, TCP-1-ε, TCPE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cct5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- T-complex protein 1, beta subunit
- thermosome, various subunits, archaeal
- T-complex protein 1, alpha subunit
- protein binding
- TCP-1/cpn60 chaperonin family
- mRNA 3' UTR binding
- mRNA 5' UTR binding
- T-complex protein 1, zeta subunit
- T-complex protein 1, eta subunit
- T-complex protein 1, delta subunit
- T-complex protein 1, gamma subunit
- chaperonin_like
- apical domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- primary ovarian cancer
- colon cancer
- autosomal recessive hereditary sensory neuropathy with spastic paralegia
role in cell
- expression in
- cell death
- binding
- growth
- signaling in
- accumulation in
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- Nucleus
- centrosome
- microtubules
- cytosol
- nucleoli
- perikaryon
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cct5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- chaperone-mediated protein folding
- positive regulation of telomere maintenance via telomerase
- protein stabilization
- protein folding
- response to virus
Cellular Component
Where in the cell the gene product is active
- chaperonin-containing T-complex
- centrosome
- extracellular vesicular exosome
- cell body
- cytosol
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- protein binding involved in protein folding
- mRNA 5'-UTR binding
- G-protein beta-subunit binding
- beta-tubulin binding
- unfolded protein binding
- mRNA 3'-UTR binding