Uchl3 Gene Summary [Mouse]
Enables deubiquitinase activity. Involved in cellular response to insulin stimulus; positive regulation of fat cell differentiation; and protein catabolic process. Acts upstream of or within several processes, including adult walking behavior; eating behavior; and protein deubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including embryo ectoderm; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human UCHL3 (ubiquitin C-terminal hydrolase L3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Uchl3 |
| Official Name | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) [Source:MGI Symbol;Acc:MGI:1355274] |
| Ensembl ID | ENSMUSG00000022111 |
| Bio databases IDs | |
| Aliases | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) |
| Synonyms | LOC120097061, LOC679036, RGD1561196, ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase), ubiquitin C-terminal hydrolase L3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uchl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin thiolesterase
- NEDD8-specific protease
- polygalacturonase
- catalytic domain
- peptidase
- ubiquitin-specific protease
- ubiquitin binding
- protein binding
- cysteine peptidase C12
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Uchl3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- obesity
- diabetic retinopathy
- metastasis
- tumorigenesis
- insulin resistance
- serous ovarian adenocarcinoma
- serous ovarian cancer
- ovarian cancer
role in cell
- proliferation
- growth
- phosphorylation in
- expression in
- migration
- activation in
- cell viability
- signaling in
- differentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uchl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- protein catabolic process
- post-translational protein modification
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- ubiquitin binding
- NEDD8-specific protease activity
- peptidase activity