Popdc3 Gene Summary [Mouse]

Enables cAMP binding activity. Acts upstream of or within regulation of membrane potential. Located in membrane. Is expressed in several structures, including gut; heart; leg muscle; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy. Orthologous to human POPDC3 (popeye domain cAMP effector 3). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Popdc3
Official Name
popeye domain containing 3 [Source:MGI Symbol;Acc:MGI:1930153]
Ensembl ID
ENSMUSG00000019848
Bio databases IDs NCBI: 78977 Ensembl: ENSMUSG00000019848
Aliases popeye domain containing 3
Synonyms bA355M14.1, LGMDR26, POP3, Popeye 3, popeye domain cAMP effector 3, popeye domain containing 3
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Popdc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • 3',5'-cAMP binding
  • Popeye protein conserved region
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • autosomal recessive limb-girdle muscular dystrophy type 26
  • prostate cancer
  • multiple sclerosis
  • limb-girdle muscular dystrophy type 2
regulated by
  • GRIN3A
  • HOXB13
  • Small T Antigen
  • pirinixic acid
  • androgen
  • tetrodotoxin
  • fenofibrate
role in cell
  • transmembrane potential

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Popdc3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • heart development
  • regulation of membrane potential
  • striated muscle cell differentiation
  • skeletal muscle tissue development

Cellular Component

Where in the cell the gene product is active
  • sarcolemma
  • membrane

Molecular Function

What the gene product does at the molecular level
  • cAMP binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.