Hoxb13 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Acts upstream of or within epithelial cell maturation involved in prostate gland development; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; and regulation of growth. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb bud; and tail. Human ortholog(s) of this gene implicated in ductal carcinoma in situ and renal cell carcinoma. Orthologous to human HOXB13 (homeobox B13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxb13 |
| Official Name | homeobox B13 [Source:MGI Symbol;Acc:MGI:107730] |
| Ensembl ID | ENSMUSG00000049604 |
| Bio databases IDs | |
| Aliases | homeobox B13 |
| Synonyms | homeo box B13, HPC9, PSGD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxb13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- methyl-CpG binding
- Hox protein A13 N terminal
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- invasive breast cancer
- neoplasia
- epithelial cancer
- cancer
- epithelial neoplasia
- metastasis
- prostate cancer
- pancreatic cancer
- prostatic carcinoma
- prostatic adenocarcinoma
role in cell
- expression in
- proliferation
- apoptosis
- growth
- differentiation
- signaling in
- formation
- invasion by
- G1 phase
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxb13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- angiogenesis
- epidermis development
- response to wounding
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
- response to testosterone stimulus
- regulation of growth
- epithelial cell maturation involved in prostate gland development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- methyl-CpG binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity