Fgd6 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in cerebral cortex. Orthologous to human FGD6 (FYVE, RhoGEF and PH domain containing 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgd6 |
| Official Name | FYVE, RhoGEF and PH domain containing 6 [Source:MGI Symbol;Acc:MGI:1261419] |
| Ensembl ID | ENSMUSG00000020021 |
| Bio databases IDs | |
| Aliases | FYVE, RhoGEF and PH domain containing 6 |
| Synonyms | ETOHD4, FLJ11183, FYVE, RhoGEF and PH domain containing 6, KIAA1362, RGD1565609, ZFYVE24 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgd6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- RhoGEF
- Protein present in Fab1, YOTB, Vac1, and EEA1
- guanyl-nucleotide exchange factor
- PH domain
- enzyme binding
- PHD finger superfamily
- protein binding
- Pleckstrin homology-like domain
- Pleckstrin homology domain
- RhoGEF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon epithelial cancer
- exudative age-related macular degeneration
- pancreatic cancer
- pancreatic ductal adenocarcinoma
- colon carcinoma
- endometriosis
- myocardial infarction
- pancreatic epithelial cancer
- organismal death
- angina pectoris
regulated by
- beta-estradiol
regulates
role in cell
- macropinocytosis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- Golgi Apparatus
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgd6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cytoskeleton organization
- regulation of GTPase activity
- actin cytoskeleton organization
- filopodium assembly
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- ruffle
- Golgi apparatus
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding