Tgfbr2 Gene Summary [Mouse]
Enables several functions, including SMAD binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity. Involved in several processes, including circulatory system development; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; and skeletal system development. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of tolerance induction; and respiratory system development. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; embryo mesenchyme; genitourinary system; and nervous system. Used to study DiGeorge syndrome; Loeys-Dietz syndrome; cleft soft palate; lung cancer; and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tgfbr2 |
| Official Name | transforming growth factor, beta receptor II [Source:MGI Symbol;Acc:MGI:98729] |
| Ensembl ID | ENSMUSG00000032440 |
| Bio databases IDs | |
| Aliases | transforming growth factor, beta receptor II |
| Synonyms | 1110020H15Rik, AAT3, DNIIR, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, RIIDN, TAAD2, TbetaR-II, TBR-II, TBRLL, TGFbeta1R2, TGF-beta 2, Tgf beta2 receptor, TGF-beta receptor 2, TGF-beta receptor type 2, TGF beta receptor type II, TGFbeta-RII, Tgfbr2T, TGFB receptor II, Tgfbrii, TGFR-2, TGFβ1R2, TGF-β 2, TGF-β receptor 2, TGF-β receptor type 2, TGF β receptor type II, Tgf-β RII, Tgf-β type ii receptor, transforming growth factor beta receptor 2, transforming growth factor, beta receptor 2, transforming growth factor, beta receptor II, transforming growth factor β receptor 2, transforming growth factor, β receptor 2, transforming growth factor, β receptor II, type 2 TGF-β receptors, T β r2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tgfbr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- protein serine/threonine kinase
- TGFbeta binding
- Protein kinase domain
- transforming growth factor-beta receptor
- transmembrane receptor protein serine/threonine kinase
- N-linked glycosylation site
- cytoplasmic domain
- intracellular domain
- tail domain
- membrane-proximal domain
- TFP
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- cytoplasmic kinase domain
- extracellular domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- serine/threonine kinase domain
- protein binding
- glycosaminoglycan binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- type II transforming growth factor-beta receptor
- Protein Kinases, catalytic domain
- transforming growth factor-beta receptor binding
- transmembrane domain
- protein homodimerization
- Transforming growth factor beta receptor 2 ectodomain
- kinase activator
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Tgfbr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Antiproliferative Role of TOB in T Cell Signaling
- Epithelial Adherens Junction Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- GADD45 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glucocorticoid Receptor Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Inhibition of Angiogenesis by TSP1
- NF-κB Signaling
- p38 MAPK Signaling
- Pancreatic Adenocarcinoma Signaling
- Protein Kinase A Signaling
- PTEN Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Tissue Factor in Cancer
- SPINK1 Pancreatic Cancer Pathway
- STAT3 Pathway
- T Helper Cell Differentiation
- TGF-β Signaling
- Th1 and Th2 Activation Pathway
- Th2 Pathway
- Tight Junction Signaling
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- insulin-dependent diabetes mellitus
- lung squamous cell carcinoma
- biliary tract cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- benign neoplasia
- metastasis
- glioma formation
role in cell
- cell viability
- expression in
- cell death
- apoptosis
- proliferation
- survival
- cellular infiltration
- quantity
- frequency
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cytoskeleton
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- membrane surface
- cellular membrane
- vesicles
- intercellular junctions
- cell-cell contacts
- cytosol
- plasma membrane extracellular face
- caveolae
- nuclear bodies
- early endosomes
- endocytotic vesicle
- rough endoplasmatic reticulum
- membrane rafts
- cellular protrusions
- cell membrane leading edge
- cortical vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tgfbr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- trachea formation
- mammary gland morphogenesis
- embryonic hemopoiesis
- transforming growth factor beta receptor signaling pathway
- lens development in camera-type eye
- positive regulation of angiogenesis
- activin receptor signaling pathway
- in utero embryonic development
- apoptotic process
- heart looping
- response to cholesterol
- aortic valve morphogenesis
- atrioventricular valve morphogenesis
- SMAD protein signal transduction
- smoothened signaling pathway
- artery morphogenesis
- tricuspid valve morphogenesis
- positive regulation of mesenchymal cell proliferation
- brain development
- bronchus morphogenesis
- positive regulation of tolerance induction to self antigen
- cardiac left ventricle morphogenesis
- aorta morphogenesis
- Notch signaling pathway
- cellular response to growth factor stimulus
- regulation of gene expression
- epithelial to mesenchymal transition
- positive regulation of CD4-positive, alpha-beta T cell proliferation
- positive regulation of NK T cell differentiation
- lung lobe morphogenesis
- positive regulation of cell proliferation
- palate development
- regulation of stem cell proliferation
- outflow tract morphogenesis
- endocardial cushion fusion
- vasculogenesis
- response to xenobiotic stimulus
- protein phosphorylation
- growth plate cartilage chondrocyte growth
- positive regulation of B cell tolerance induction
- positive regulation of epithelial to mesenchymal transition
- outflow tract septum morphogenesis
- heart development
- membranous septum morphogenesis
- blood vessel development
- patterning of blood vessels
- myeloid dendritic cell differentiation
- regulation of stem cell differentiation
- activation of protein kinase activity
- positive regulation of SMAD protein import into nucleus
- positive regulation of epithelial cell migration
- positive regulation of reactive oxygen species metabolic process
- embryonic cranial skeleton morphogenesis
- ventricular septum morphogenesis
- regulation of cell proliferation
- gastrulation
- positive regulation of T cell tolerance induction
Cellular Component
Where in the cell the gene product is active
- caveola
- transforming growth factor beta1-type II receptor-type I receptor complex
- membrane
- membrane raft
- external side of plasma membrane
- cytosol
- receptor complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- kinase activator activity
- transforming growth factor beta-activated receptor activity
- transforming growth factor beta receptor activity, type II
- transmembrane receptor protein serine/threonine kinase activity
- transforming growth factor beta binding
- ATP binding
- protein binding
- activin binding
- SMAD binding
- metal ion binding
- glycosaminoglycan binding
- activin-activated receptor activity
- type I transforming growth factor beta receptor binding
- binding, bridging