Bclaf1 Gene Summary [Mouse]
Predicted to enable DNA binding activity and transcription coregulator activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nuclear speck. Predicted to be part of mediator complex. Is expressed in several structures, including central nervous system; genitourinary system; retina; submandibular gland; and trachea. Orthologous to human BCLAF1 (BCL2 associated transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Bclaf1 |
| Official Name | BCL2-associated transcription factor 1 [Source:MGI Symbol;Acc:MGI:1917580] |
| Ensembl ID | ENSMUSG00000037608 |
| Bio databases IDs | |
| Aliases | BCL2-associated transcription factor 1 |
| Synonyms | 2610102K23RIK, 2700025J07Rik, 2810454G14Rik, 5730534O06Rik, Aa2-041, BCL2-associated transcription factor 1, bK211L9.1, BTF, KIAA0164, mKIAA0164 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bclaf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- THRAP3/BCLAF1 family
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- chromosomal instability
- B-cell prolymphocytic leukemia
- organismal death
- preeclampsia
- prostatic carcinoma
- prostate cancer
- Waldenström macroglobulinemia
role in cell
- expression in
- apoptosis
- proliferation
- quantity
- differentiation
- number
- survival
- degradation in
- G2/M phase
- splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bclaf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- positive regulation of apoptotic process
- apoptotic process
- positive regulation of transcription initiation, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- transcription cofactor activity
- protein binding
- RNA binding