Pdgfrb Gene Summary [Mouse]
Enables platelet-derived growth factor receptor activity and signaling receptor binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; protein phosphorylation; and vasculature development. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; response to ceramide; and ruffle assembly. Located in cell surface; cytoplasm; and ruffle. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Used to study several diseases, including autism spectrum disorder; basal ganglia calcification; infantile myofibromatosis; myeloproliferative neoplasm; and severe nonproliferative diabetic retinopathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm; and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdgfrb |
| Official Name | platelet derived growth factor receptor, beta polypeptide [Source:MGI Symbol;Acc:MGI:97531] |
| Ensembl ID | ENSMUSG00000024620 |
| Bio databases IDs | |
| Aliases | platelet derived growth factor receptor, beta polypeptide |
| Synonyms | CD140B, IBGC4, IMF1, JTK12, KOGS, PDFGR-beta, PDFGR-β, PDGFbetaR, PDGFR, PDGFR-1, PDGF-R-beta, Pdgf receptor β, PDGF-R-β, Pdgf-β receptor, PENTT, platelet derived growth factor receptor beta, platelet derived growth factor receptor, beta polypeptide, platelet derived growth factor receptor β, platelet derived growth factor receptor, β polypeptide, platelet-derived growth factor-β receptors, β PDGF receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdgfrb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PI3K binding domain
- Src binding domain
- protein kinase
- GTPase activator
- protein-tyrosine kinase
- Protein kinase domain
- kinase insertion domain
- phospholipase activator
- cytoplasmic domain
- ligand-binding domain
- Immunoglobulin like
- intracellular domain
- immunoglobulin-like protein domain
- Syp binding domain
- membrane-proximal domain
- platelet-derived growth factor receptor beta
- Tyrosine kinase, catalytic domain
- growth factor binding
- transmembrane receptor
- SHP-2 binding domain
- GTPase activating protein binding domain
- extracellular domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- YXXM motif
- Protein tyrosine and serine/threonine kinase
- ectodomain
- immunoglobulin domain
- platelet-derived growth factor receptor binding
- Immunoglobulin I-set domain
- enzyme binding
- SH-PTP2 binding domain
- autophosphorylation site
- protein binding
- receptor binding
- phosphorylation site
- kinase
- PLC gamma binding domain
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- phosphoinositide 3-kinase binding
- Protein Kinases, catalytic domain
- PLC gamma1 protein binding domain
- platelet-derived growth factor receptor
- transmembrane domain
- tyrosine kinase domain
- PDZ binding motif
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Pdgfrb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Apelin Liver Signaling Pathway
- CREB Signaling in Neurons
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Human Embryonic Stem Cell Pluripotency
- IL-15 Production
- Iron homeostasis signaling pathway
- NF-κB Signaling
- PAK Signaling
- PDGF Signaling
- PPAR Signaling
- PTEN Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of PKR in Interferon Induction and Antiviral Response
- Sperm Motility
- Sphingosine-1-phosphate Signaling
- STAT3 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- colorectal cancer
- benign neoplasia
- neoplasia
- thyroid cancer
- obesity
- cancer
- breast cancer
- acute lymphoblastic lymphoma
- primary T acute lymphoblastic leukemia
role in cell
- expression in
- activation
- activation in
- phosphorylation in
- apoptosis
- proliferation
- formation in
- signaling in
- formation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- caveolae fraction
- intracellular membrane-bounded organelle
- ruffle
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- cytosol
- apical membrane
- ruffled borders
- basal lamina
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdgfrb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina vasculature development in camera-type eye
- positive regulation of MAP kinase activity
- peptidyl-tyrosine phosphorylation
- cell migration involved in vasculogenesis
- cell migration involved in coronary angiogenesis
- multicellular organismal development
- positive regulation of cell proliferation
- protein autophosphorylation
- positive regulation of mitosis
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
- cell chemotaxis
- positive regulation of calcium-mediated signaling
- positive regulation of smooth muscle cell proliferation
- smooth muscle cell chemotaxis
- metanephric glomerular mesangial cell proliferation involved in metanephros development
- angiogenesis
- cardiac myofibril assembly
- positive regulation of kinase activity
- positive regulation of smooth muscle cell migration
- positive regulation of DNA biosynthetic process
- positive regulation of reactive oxygen species metabolic process
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
- G-protein coupled receptor signaling pathway
- signal transduction
- cellular response to platelet-derived growth factor stimulus
- platelet-derived growth factor receptor-beta signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- platelet-derived growth factor receptor signaling pathway
- phosphatidylinositol metabolic process
- positive regulation of calcium ion import
- aorta morphogenesis
- positive regulation of phosphoprotein phosphatase activity
- regulation of actin cytoskeleton organization
- metanephric glomerular capillary formation
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of chemotaxis
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- focal adhesion
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytoplasmic vesicle
- lysosomal lumen
- Golgi apparatus
- receptor complex
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- platelet-derived growth factor receptor binding
- protein kinase activity
- vascular endothelial growth factor binding
- platelet activating factor receptor activity
- receptor binding
- platelet-derived growth factor-activated receptor activity
- platelet-derived growth factor binding
- platelet-derived growth factor beta-receptor activity
- ATP binding
- protein tyrosine kinase activity
- protein binding
- enzyme binding