Eif4ebp2 Gene Summary [Mouse]
Enables eukaryotic initiation factor 4E binding activity and translation repressor activity. Involved in several processes, including memory; negative regulation of translational initiation; and social behavior. Acts upstream of or within TOR signaling and insulin receptor signaling pathway. Predicted to be located in nucleus. Predicted to be active in neuronal ribonucleoprotein granule and postsynapse. Is expressed in heart; liver; and lung. Used to study autism spectrum disorder. Orthologous to human EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif4ebp2 |
| Official Name | eukaryotic translation initiation factor 4E binding protein 2 [Source:MGI Symbol;Acc:MGI:109198] |
| Ensembl ID | ENSMUSG00000020091 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4E binding protein 2 |
| Synonyms | 2810011I19RIK, 4E-BP2, AA792569, BC010348, eukaryotic translation initiation factor 4E binding protein 2, PHAS-II |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif4ebp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- translation repressor
- Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
- protein binding
- eIF4E binding domain
- eukaryotic initiation factor 4E binding
- translation regulator
Pathways
Biological processes and signaling networks where the Eif4ebp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- cancer
- epithelial cancer
- seizures
- obesity
- weight gain
- head and neck squamous cell cancer
- head and neck cancer
- squamous cell cancer
- head and neck neoplasia
role in cell
- expression in
- number
- proliferation
- density
- phosphorylation in
- production in
- synthesis in
- quantity
- translation in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- organelle
- postsynaptic region
- synapse
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif4ebp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- negative regulation of translational initiation
- insulin receptor signaling pathway
- regulation of synaptic plasticity
- regulation of synaptic transmission
- TOR signaling cascade
- memory
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular non-membrane-bounded organelle
- neuronal ribonucleoprotein granule
Molecular Function
What the gene product does at the molecular level
- protein binding
- translation repressor activity
- eukaryotic initiation factor 4E binding