EIF4EBP2 Gene Summary [Human]
This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | EIF4EBP2 |
| Official Name | eukaryotic translation initiation factor 4E binding protein 2 [Source:HGNC Symbol;Acc:HGNC:3289] |
| Ensembl ID | ENSG00000148730 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4E binding protein 2 |
| Synonyms | 2810011I19RIK, 4E-BP2, AA792569, BC010348, eukaryotic translation initiation factor 4E binding protein 2, PHAS-II |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF4EBP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- translation repressor
- Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
- protein binding
- eIF4E binding domain
- eukaryotic initiation factor 4E binding
- translation regulator
Pathways
Biological processes and signaling networks where the EIF4EBP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- cancer
- epithelial cancer
- seizures
- obesity
- weight gain
- head and neck squamous cell cancer
- head and neck cancer
- squamous cell cancer
- head and neck neoplasia
role in cell
- expression in
- number
- proliferation
- density
- phosphorylation in
- production in
- synthesis in
- quantity
- translation in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- organelle
- postsynaptic region
- synapse
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF4EBP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- negative regulation of translational initiation
- insulin receptor signaling pathway
- regulation of synaptic plasticity
- regulation of synaptic transmission
- TOR signaling cascade
- memory
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular non-membrane-bounded organelle
- neuronal ribonucleoprotein granule
Molecular Function
What the gene product does at the molecular level
- protein binding
- translation repressor activity
- eukaryotic initiation factor 4E binding