Wnt1 Gene Summary [Mouse]
Enables cytokine activity and protein domain specific binding activity. Involved in several processes, including astrocyte-dopaminergic neuron signaling; central nervous system development; and embryonic brain development. Acts upstream of or within several processes, including hemopoiesis; nervous system development; and regulation of protein metabolic process. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo ectoderm; and genitourinary system. Used to study breast cancer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15. Orthologous to human WNT1 (Wnt family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnt1 |
| Official Name | wingless-type MMTV integration site family, member 1 [Source:MGI Symbol;Acc:MGI:98953] |
| Ensembl ID | ENSMUSG00000022997 |
| Bio databases IDs | |
| Aliases | wingless-type MMTV integration site family, member 1 |
| Synonyms | BMND16, INT1, OI15, sw, swaying, Wg, wingless-type MMTV integration site family, member 1, Wnt family member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wnt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- morphogen
- Wnt
- wnt family
- receptor agonist activity
- protein domain specific binding
- protein binding
- receptor binding
- cytokine
- found in Wnt-1
Pathways
Biological processes and signaling networks where the Wnt1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Erythropoietin Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Neuroinflammation Signaling Pathway
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- neoplasia
- cancer
- metastasis
- epithelial neoplasia
- breast cancer
- osteogenesis imperfecta type XV
- hyperplasia
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
role in cell
- cell death
- activation
- quantity
- migration
- activity
- accumulation in
- apoptosis
- activation in
- assembly
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- Plasma Membrane
- endoplasmic reticulum lumen
- extracellular matrix
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wnt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell-cell adhesion
- positive regulation of cell proliferation
- signal transduction in response to DNA damage
- response to wounding
- forebrain anterior/posterior pattern specification
- fat cell differentiation
- embryonic axis specification
- diencephalon development
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- central nervous system morphogenesis
- positive regulation of Notch signaling pathway
- midbrain-hindbrain boundary maturation during brain development
- bone development
- positive regulation of insulin-like growth factor receptor signaling pathway
- midbrain development
- positive regulation of transcription, DNA-dependent
- negative regulation of cell-substrate adhesion
- hepatocyte differentiation
- neuron fate determination
- positive regulation of fibroblast proliferation
- cellular response to peptide hormone stimulus
- Wnt receptor signaling pathway
- canonical Wnt receptor signaling pathway
- cell proliferation in midbrain
- negative regulation of cellular senescence
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- positive regulation of lamellipodium assembly
- positive regulation of dermatome development
- neuron differentiation
- spinal cord association neuron differentiation
- T cell differentiation in thymus
- myoblast fusion
- cell-cell signaling
- cerebellum formation
- negative regulation of fat cell differentiation
- negative regulation of BMP signaling pathway
- negative regulation of apoptotic process
- branching involved in ureteric bud morphogenesis
- positive regulation of protein phosphorylation
- cell fate commitment
- inner ear morphogenesis
- hemopoietic stem cell proliferation
- Spemann organizer formation
- organ regeneration
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- Golgi lumen
- extracellular region
- endocytic vesicle membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein domain specific binding
- receptor agonist activity
- cytokine activity
- morphogen activity