Gabrp Gene Summary [Mouse]

Predicted to enable GABA-A receptor activity and GABA-gated chloride ion channel activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of GABA-A receptor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and skin. Orthologous to human GABRP (gamma-aminobutyric acid type A receptor subunit pi). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Gabrp
Official Name
gamma-aminobutyric acid (GABA) A receptor, pi [Source:MGI Symbol;Acc:MGI:2387597]
Ensembl ID
ENSMUSG00000020159
Bio databases IDs NCBI: 216643 Ensembl: ENSMUSG00000020159
Aliases gamma-aminobutyric acid (GABA) A receptor, pi
Synonyms GABA-A Receptor Pi Subunit, gamma-aminobutyric acid type A receptor subunit pi, γ-aminobutyric acid type A receptor subunit pi
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gabrp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • GABA-A receptor
  • transmembrane domain of Cys-loop neurotransmitter-gated ion channels
  • channel/pore class transporter
  • extracellular ligand-gated ion channel
  • Cation transporter family protein
  • ion channel
  • anion channel
  • neurotransmitter receptor
  • LGIC_ECD
  • Neurotransmitter-gated ion-channel transmembrane region
  • Neurotransmitter-gated ion-channel ligand binding domain
  • chloride channel
  • ligand-gated ion channel

Pathways

Biological processes and signaling networks where the Gabrp gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • H1-4
  • estazolam
  • felbamate
  • secobarbital
  • alphadolone
  • oxazepam
  • isoflurane
  • temazepam
  • quazepam
  • isoniazid
disease
  • major depression
  • depressive disorder
  • cognitive impairment
  • dementia
  • schizophrenia
  • anxiety disorder
  • pain
  • disorder of coronary artery
  • infection
  • HIV infection
regulated by
  • beta-estradiol
  • BMP4
  • A-83-01
  • PD173074
  • AKT1
  • zolpidem
  • phenobarbital
  • Gstp1 (includes others)
  • chlordiazepoxide
  • tetradecanoylphorbol acetate
role in cell
  • growth

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Gabrp gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of membrane potential
  • synaptic transmission

Cellular Component

Where in the cell the gene product is active
  • chloride channel complex
  • synapse
  • neuron projection
  • apical plasma membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • GABA-A receptor activity
  • neurotransmitter receptor activity
  • chloride channel activity
  • GABA-gated chloride ion channel activity