Gabrp Gene Summary [Rat]
Enables GABA-gated chloride ion channel activity. Contributes to GABA-A receptor activity. Predicted to be involved in chloride transmembrane transport. Located in plasma membrane. Orthologous to human GABRP (gamma-aminobutyric acid type A receptor subunit pi). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabrp |
| Official Name | gamma-aminobutyric acid type A receptor pi subunit [Source:RGD Symbol;Acc:620532] |
| Ensembl ID | ENSRNOG00000032417 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid type A receptor pi subunit |
| Synonyms | GABA-A Receptor Pi Subunit, gamma-aminobutyric acid type A receptor subunit pi, γ-aminobutyric acid type A receptor subunit pi |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gabrp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- ion channel
- anion channel
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- chloride channel
- ligand-gated ion channel
Pathways
Biological processes and signaling networks where the Gabrp gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- H1-4
- estazolam
- felbamate
- secobarbital
- alphadolone
- oxazepam
- isoflurane
- temazepam
- quazepam
- isoniazid
disease
- major depression
- depressive disorder
- cognitive impairment
- dementia
- schizophrenia
- anxiety disorder
- pain
- disorder of coronary artery
- infection
- HIV infection
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gabrp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of membrane potential
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- synapse
- neuron projection
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GABA-A receptor activity
- neurotransmitter receptor activity
- chloride channel activity
- GABA-gated chloride ion channel activity