Trappc12 Gene Summary [Mouse]
Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of protein localization to kinetochore; and regulation of kinetochore assembly. Predicted to be located in kinetochore and nucleoplasm. Predicted to be part of TRAPP complex. Predicted to be active in Golgi apparatus. Predicted to colocalize with endoplasmic reticulum-Golgi intermediate compartment and perinuclear region of cytoplasm. Orthologous to human TRAPPC12 (trafficking protein particle complex subunit 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trappc12 |
| Official Name | trafficking protein particle complex 12 [Source:MGI Symbol;Acc:MGI:2445089] |
| Ensembl ID | ENSMUSG00000020628 |
| Bio databases IDs | |
| Aliases | trafficking protein particle complex 12 |
| Synonyms | CGI-87, D930014A20RIK, LOC101927578, PEBAS, RGD1566054, trafficking protein particle complex 12, trafficking protein particle complex subunit 12, TTC-15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trappc12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tetratricopeptide repeats
- protein binding
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- early-onset progressive encephalopathy with brain atrophy and spasticity
- alcoholism
- childhood progressive encephalopathy
- cerebral amyloid angiopathy
- hereditary disorder
regulated by
- eptifibatide
- SLC2A5
- collagen-related peptide
regulates
role in cell
- growth
- organization
- autophagy in
- assembly
- autophagy
- chromosomal congression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perinuclear region
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- nucleoplasm
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trappc12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- metaphase plate congression
- ER to Golgi vesicle-mediated transport
- regulation of kinetochore assembly
- Golgi organization
- COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- TRAPP complex
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- Golgi apparatus
- kinetochore
- endoplasmic reticulum-Golgi intermediate compartment
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding