Trappc6b Gene Summary [Mouse]
Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in cytoplasm. Predicted to be part of TRAPP complex. Predicted to be active in cis-Golgi network and trans-Golgi network. Is expressed in ganglia; trigeminal nerve; and ventral grey horn. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy. Orthologous to human TRAPPC6B (trafficking protein particle complex subunit 6B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trappc6b |
| Official Name | trafficking protein particle complex 6B [Source:MGI Symbol;Acc:MGI:1925482] |
| Ensembl ID | ENSMUSG00000020993 |
| Bio databases IDs | |
| Aliases | trafficking protein particle complex 6B |
| Synonyms | 5830498C14Rik, NEDMEBA, RGD1309325, TPC6, trafficking protein particle complex 6B, trafficking protein particle complex subunit 6B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trappc6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transport protein particle (TRAPP) component
- protein binding
- Bet3-like domains of TRAPP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trappc6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle coating
- ER to Golgi vesicle-mediated transport
- nervous system development
Cellular Component
Where in the cell the gene product is active
- TRAPP complex
- trans-Golgi network
- cis-Golgi network
- cytoplasm
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding