Trappc11 Gene Summary [Mouse]
Predicted to be involved in several processes, including constitutive secretory pathway; endoplasmic reticulum to Golgi vesicle-mediated transport; and regulation of protein complex stability. Predicted to be located in Golgi apparatus. Predicted to be part of TRAPP complex. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2S. Orthologous to human TRAPPC11 (trafficking protein particle complex subunit 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trappc11 |
| Official Name | trafficking protein particle complex 11 [Source:MGI Symbol;Acc:MGI:2444585] |
| Ensembl ID | ENSMUSG00000038102 |
| Bio databases IDs | |
| Aliases | trafficking protein particle complex 11 |
| Synonyms | AW558465, C4orf41, D030016E14Rik, FOIGR, GRY, LGMD2S, LGMDR18, R75422, RGD1309765, trafficking protein particle complex 11, trafficking protein particle complex subunit 11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trappc11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Gryzun, putative trafficking through Golgi
- Foie gras liver health family 1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- limb-girdle muscular dystrophy type 2
- limb-girdle muscular dystrophy type 2S
- acute myeloid leukemia
- muscular dystrophy
- autosomal recessive limb-girdle muscular dystrophy type 23
- ischemic stroke
- limb-girdle muscular dystrophy
- hereditary disorder
- systemic lupus erythematosus
role in cell
- accumulation in
- organization
- hypoglycosylation in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trappc11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- constitutive secretory pathway
- Golgi organization
- COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- TRAPP complex
- cytoplasm
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding