Fbxo7 Gene Summary [Mouse]
Enables protein kinase binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and negative regulation of lymphocyte differentiation. Located in mitochondrion and nucleus. Is expressed in dorsal root ganglion; gallbladder; liver; trigeminal ganglion; and vagus ganglion. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 15. Orthologous to human FBXO7 (F-box protein 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo7 |
| Official Name | F-box protein 7 [Source:MGI Symbol;Acc:MGI:1917004] |
| Ensembl ID | ENSMUSG00000001786 |
| Bio databases IDs | |
| Aliases | F-box protein 7 |
| Synonyms | 2410015K21RIK, A230052G17RIK, AI117679, AW260462, F-box protein 7, FBX, FBX07, FBX7, PARK15, PKPS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxo7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein kinase binding
- nuclear export signal
- F-box domain superfamily
- protein binding activity, bridging
- ubiquitin binding
- enzyme
- protein binding
- ubiquitin-like domain
- proline rich domain
- PI31 proteasome regulator N-terminal
- F-box domain
- Ubl1_cv_Nsp3_N-like
- ubiquitin-protein transferase activity
- F-box-like
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- Parkinson disease 15
- organismal death
- endometrial carcinoma
- epithelial endometrial cancer
- motor dysfunction
- ovarian cancer
- renal cell carcinoma
- renal cell cancer
role in cell
- proliferation
- apoptosis
- expression in
- acetylation in
- migration
- invasion by
- accumulation in
- differentiation
- cell death
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxo7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- regulation of locomotion
- negative regulation of lymphocyte differentiation
- mitochondrion degradation
- ubiquitin-dependent protein catabolic process
- protein targeting to mitochondrion
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of protein stability
- negative regulation of G1/S transition of mitotic cell cycle
- lymphocyte differentiation
- regulation of neuron projection development
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- mitochondrion
- cytosol
- SCF ubiquitin ligase complex
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein kinase binding
- ubiquitin protein ligase binding
- protein binding
- ubiquitin binding
- protein heterodimerization activity