Cenpo Gene Summary [Mouse]
Predicted to be involved in chromosome segregation. Predicted to be located in nuclear body. Predicted to be part of Mis6-Sim4 complex. Is expressed in several structures, including central nervous system; genitourinary system; jaw; sensory organ; and thymus primordium. Orthologous to human CENPO (centromere protein O). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cenpo |
| Official Name | centromere protein O [Source:MGI Symbol;Acc:MGI:1923800] |
| Ensembl ID | ENSMUSG00000020652 |
| Bio databases IDs | |
| Aliases | centromere protein O |
| Synonyms | 2810429O05Rik, 8430427C03Rik, centromere protein O, D12Ertd482e, ICEN-36, MCM21R, MGC11266 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cenpo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RWD, DRWD, and ELF domain family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- urothelial bladder carcinoma
- esophageal cancer
- squamous cell lung cancer
- coronary artery disease
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- liver cancer
regulated by
- dexamethasone
- MITF
role in cell
- phosphorylation in
- expression in
- apoptosis
- migration
- proliferation
- G2/M phase
- invasion by
- cohesion in
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cenpo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centromere complex assembly
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome inner kinetochore
- nuclear body
- cytosol
- nucleoplasm
- Mis6-Sim4 complex
Molecular Function
What the gene product does at the molecular level
- protein binding