Cenpu Gene Summary [Mouse]
Acts upstream of or within chordate embryonic development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; gonad; hemolymphoid system; and sensory organ. Orthologous to human CENPU (centromere protein U). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cenpu |
| Official Name | centromere protein U [Source:MGI Symbol;Acc:MGI:1919126] |
| Ensembl ID | ENSMUSG00000031629 |
| Bio databases IDs | |
| Aliases | centromere protein U |
| Synonyms | 1700029A22RIK, CENP50, CENPU50, centromere protein U, FLJ23468, KLIP1, MLF1IP, PBIP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cenpu often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CENP-A nucleosome associated complex (NAC) subunit
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- renal cell cancer
- invasive breast cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- metastasis
- organismal death
- breast carcinoma
- Kawasaki disease
role in cell
- expression in
- proliferation
- migration
- degradation in
- upregulation in
- invasion by
- cohesion
- cohesion in
- misorientation in
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cenpu gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chordate embryonic development
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome inner kinetochore
- centriolar satellite
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding