Nxf1 Gene Summary [Mouse]
Enables mRNA binding activity. Acts upstream of or within poly(A)+ mRNA export from nucleus. Located in nuclear inclusion body. Part of nuclear pore. Is expressed in several structures, including central nervous system; genitourinary system; liver; sensory organ; and spleen. Orthologous to human NXF1 (nuclear RNA export factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nxf1 |
| Official Name | nuclear RNA export factor 1 [Source:MGI Symbol;Acc:MGI:1858330] |
| Ensembl ID | ENSMUSG00000010097 |
| Bio databases IDs | |
| Aliases | nuclear RNA export factor 1 |
| Synonyms | MEX67, MEX67H, Mvb1, nuclear RNA export factor 1, TAP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nxf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- TAP C-terminal domain
- nuclear export signal
- UBA-like domain
- mRNA binding
- Tap, RNA-binding
- nuclear localization sequence
- Leucine rich repeat
- central domain
- protein binding
- Leucine Rich repeats (2 copies)
- RNA binding
- leucine-rich repeat
- NXT1 binding domain
- NTF2_like
- RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- pemphigus foliaceus
- infection by HIV-1
role in cell
- replication in
- cell death
- molecular cleavage in
- accumulation in
- assembly in
- alternative splicing in
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- Cytoplasm
- Plasma Membrane
- cytosol
- nuclear pores
- nucleoplasm
- nuclear rim
- nuclear envelope
- nuclear speckles
- apical processes
- detergent-soluble fraction
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nxf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- protein transport
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nuclear inclusion body
- nucleus
- cytoplasmic stress granule
- cytoplasm
- nuclear RNA export factor complex
- nuclear speck
- cytosol
- transcription export complex
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding