Gas2l2 Gene Summary [Mouse]
Enables G-protein alpha-subunit binding activity. Involved in positive regulation of G protein-coupled receptor signaling pathway and regulation of cilium beat frequency involved in ciliary motility. Colocalizes with ciliary basal body and plasma membrane. Used to study primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 41. Orthologous to human GAS2L2 (growth arrest specific 2 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gas2l2 |
| Official Name | growth arrest-specific 2 like 2 [Source:MGI Symbol;Acc:MGI:3652048] |
| Ensembl ID | ENSMUSG00000020686 |
| Bio databases IDs | |
| Aliases | growth arrest-specific 2 like 2 |
| Synonyms | CILD41, GAR17, Gas2, growth arrest-specific 2 like 2, LOC100912215, LOC103694862, LOC108348322 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gas2l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- microtubule binding
- Calponin homology domain
- calponin homology (CH) domain superfamily
- protein binding
- glycine arginine rich domain
- Growth-Arrest-Specific Protein 2 Domain
- cytoskeletal adaptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- basal bodies
- microtubules
- actin filaments
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gas2l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin crosslink formation
- microtubule bundle formation
- regulation of cilium beat frequency involved in ciliary motility
- regulation of microtubule polymerization or depolymerization
- positive regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- microtubule plus end
- cytoplasm
- stress fiber
- actin filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- cytoskeletal adaptor activity
- protein binding
- G-protein alpha-subunit binding
- microtubule binding