Hmbox1 Gene Summary [Mouse]
Enables telomeric DNA binding activity. Involved in telomere maintenance via telomerase. Located in chromosome, telomeric region and nucleus. Is expressed in several structures, including central nervous system; early conceptus; female reproductive system; limb mesenchyme; and urinary system. Orthologous to human HMBOX1 (homeobox containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmbox1 |
| Official Name | homeobox containing 1 [Source:MGI Symbol;Acc:MGI:2445066] |
| Ensembl ID | ENSMUSG00000021972 |
| Bio databases IDs | |
| Aliases | homeobox containing 1 |
| Synonyms | AI451877, AI604847, F830020C16Rik, FLJ21616, HNF1LA, homeobox containing 1, HOT1, LOC100912983, PBHNF, RGD1306787, TAH1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hmbox1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded telomeric DNA binding
- binding protein
- Hepatocyte nuclear factor 1 (HNF-1), N terminus
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- identical protein binding
- telomeric DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- nuclear bodies
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hmbox1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of telomerase activity
- positive regulation of telomerase activity
- positive regulation of chromatin binding
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of telomere maintenance via telomerase
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- centrosome
- nuclear body
- PML body
- cytoplasm
- Cajal body
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- telomeric DNA binding
- double-stranded telomeric DNA binding
- sequence-specific DNA binding