Nap1l1 Gene Summary [Mouse]
Predicted to enable several functions, including chromatin binding activity; histone binding activity; and histone chaperone activity. Involved in positive regulation of neural precursor cell proliferation and positive regulation of neurogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including blood; forebrain; genitourinary system; liver; and nucleus pulposus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human NAP1L1 (nucleosome assembly protein 1 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nap1l1 |
| Official Name | nucleosome assembly protein 1-like 1 [Source:MGI Symbol;Acc:MGI:1855693] |
| Ensembl ID | ENSMUSG00000058799 |
| Bio databases IDs | |
| Aliases | nucleosome assembly protein 1-like 1 |
| Synonyms | D10Ertd68e, Dn38, NAP, NAP-1, NAP1L, NAP1-LIKE, NRP, nucleosome assembly protein 1-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nap1l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nucleosome assembly protein (NAP)
- kinase binding
- PTZ00007
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- epithelial cancer
- rheumatoid arthritis
- cancer
- lymphomagenesis
- lung adenocarcinoma formation
- lung cancer
- non-squamous non-small cell lung cancer
- lung carcinoma process
- epithelial neoplasia
role in cell
- proliferation
- differentiation
- bundling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nap1l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication
- positive regulation of cell proliferation
- nervous system development
- positive regulation of neural precursor cell proliferation
- positive regulation of neurogenesis
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- melanosome
- membrane
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- histone binding
- chromatin binding