Galr2 Gene Summary [Mouse]
Predicted to enable galanin receptor activity; neuropeptide binding activity; and peptide hormone binding activity. Acts upstream of or within neuron projection development. Predicted to be located in cilium. Predicted to be active in plasma membrane. Orthologous to human GALR2 (galanin receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Galr2 |
| Official Name | galanin receptor 2 [Source:MGI Symbol;Acc:MGI:1337018] |
| Ensembl ID | ENSMUSG00000020793 |
| Bio databases IDs | |
| Aliases | galanin receptor 2 |
| Synonyms | GAL2-R, Galanin receptor, galanin receptor 2, GALNR2, LOC100910349, LOC103690156, mGalR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Galr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- neuropeptide binding
- Cholecystokinin A receptor, N-terminal
- galanin receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the Galr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- obesity
- polycystic ovary syndrome
- pheochromocytoma
- pheochromocytoma formation
role in cell
- proliferation
- apoptosis
- formation
- cell cycle progression
- morphogenesis
- elevation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cilia
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Galr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate metabolic process
- neuron projection development
- feeding behavior
- cell surface receptor signaling pathway
- phosphatidylinositol metabolic process
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- elevation of cytosolic calcium ion concentration
- learning or memory
- neuropeptide signaling pathway
- muscle contraction
Cellular Component
Where in the cell the gene product is active
- membrane
- cilium
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neuropeptide binding
- galanin receptor activity
- protein binding
- peptide hormone binding