Aloxe3 Gene Summary [Mouse]
Enables hydroperoxy icosatetraenoate isomerase activity. Involved in several processes, including establishment of skin barrier; long-chain fatty acid metabolic process; and peroxisome proliferator activated receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Is expressed in epidermis and skin. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1 and autosomal recessive congenital ichthyosis 3. Orthologous to human ALOXE3 (arachidonate epidermal lipoxygenase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aloxe3 |
| Official Name | arachidonate lipoxygenase 3 [Source:MGI Symbol;Acc:MGI:1345140] |
| Ensembl ID | ENSMUSG00000020892 |
| Bio databases IDs | |
| Aliases | arachidonate lipoxygenase 3 |
| Synonyms | arachidonate epidermal lipoxygenase 3, arachidonate lipoxygenase 3, ARCI3, E-LOX, e-LOX-3, LI5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aloxe3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- intramolecular transferase activity, transferring hydroxy groups
- PLAT
- enzyme
- protein binding
- single donor 2 atom incorporation:oxygen oxidoreductase
- Lipoxygenase homology 2 (beta barrel) domain
Pathways
Biological processes and signaling networks where the Aloxe3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive congenital ichthyosis type 3
- lamellar ichthyosis
- psoriasis
- colorectal cancer
- allodynia
- autosomal recessive ichthyosis
- desquamation
- autosomal recessive congenital ichthyosis type 2
- hyperkeratosis
- skin barrier defect
regulates
- luciferase reporter gene
- hepoxilin B3
- linoleic acid
- lipid
- omega-O-acylceramide
- omega-O-acylphytoceramide
- omega-O-acylglucosylceramide
- arachidonic acid
- hepoxilin
- sphingolipid
role in cell
- formation in
- differentiation
- transactivation in
- adipogenesis
- adipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aloxe3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hepoxilin biosynthetic process
- lipoxygenase pathway
- lipid oxidation
- linoleic acid metabolic process
- sensory perception of pain
- ceramide biosynthetic process
- fat cell differentiation
- arachidonic acid metabolic process
- peroxisome proliferator activated receptor signaling pathway
- establishment of skin barrier
- sphingolipid metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- intramolecular transferase activity, transferring hydroxy groups
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
- protein binding
- iron ion binding
- hepoxilin A3 synthase activity