Zfhx4 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; retina; and skin. Orthologous to human ZFHX4 (zinc finger homeobox 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfhx4 |
| Official Name | zinc finger homeodomain 4 [Source:MGI Symbol;Acc:MGI:2137668] |
| Ensembl ID | ENSMUSG00000025255 |
| Bio databases IDs | |
| Aliases | zinc finger homeodomain 4 |
| Synonyms | A930021B15, C130041O22Rik, RGD1563022, ZFH4, ZHF4, zinc finger homeobox 4, zinc finger homeodomain 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfhx4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- non-melanoma skin cancer
- insomnia
- neurodevelopmental disorder
- hypoplasia
- hepatocellular carcinoma
- hereditary congenital ptosis 1
- major depression
- cyanosis
role in cell
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfhx4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity