Acly Gene Summary [Mouse]
Enables ATP citrate synthase activity. Predicted to be involved in acetyl-CoA biosynthetic process and carboxylic acid metabolic process. Located in mitochondrion. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACLY (ATP citrate lyase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acly |
| Official Name | ATP citrate lyase [Source:MGI Symbol;Acc:MGI:103251] |
| Ensembl ID | ENSMUSG00000020917 |
| Bio databases IDs | |
| Aliases | ATP citrate lyase |
| Synonyms | A730098H14RIK, ACL, ATP CITRATE LYASE, ATPCL, CITRATE LYASE, CLATP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acly often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- succinyl-CoA synthetase, alpha subunit
- succinyl-CoA synthetase, beta subunit
- ATP-grasp domain
- ATP binding
- enzyme
- protein binding
- CoA binding domain
- ATP citrate lyase citrate-binding
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- CoA-ligase
- CS_ACL-C_CCL
- ATP citrate synthase
Pathways
Biological processes and signaling networks where the Acly gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- organismal death
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- disorder of lipid metabolism
- heterozygous sporadic hypercholesterolemia
- heterozygous familial hypercholesterolemia
- neoplastic cell transformation
role in cell
- expression in
- formation
- formation in
- proliferation
- incorporation in
- synthesis in
- apoptosis
- production in
- survival
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- ficolin-1-rich granule lumen
- azurophil granule lumen
- Extracellular Space
- cell cortex
- Nucleus
- basal bodies
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acly gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oxaloacetate metabolic process
- acetyl-CoA biosynthetic process
- citrate metabolic process
- cholesterol biosynthetic process
- lipid biosynthetic process
- coenzyme A metabolic process
- fatty acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- cytosol
- extracellular region
- azurophil granule lumen
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- ATP citrate synthase activity
- metal ion binding