ACLY Gene Summary [Human]
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | ACLY |
| Official Name | ATP citrate lyase [Source:HGNC Symbol;Acc:HGNC:115] |
| Ensembl ID | ENSG00000131473 |
| Bio databases IDs | |
| Aliases | ATP citrate lyase, ATP citrate synthase |
| Synonyms | A730098H14RIK, ACL, ATP CITRATE LYASE, ATPCL, CITRATE LYASE, CLATP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACLY often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- succinyl-CoA synthetase, alpha subunit
- succinyl-CoA synthetase, beta subunit
- ATP-grasp domain
- ATP binding
- enzyme
- protein binding
- CoA binding domain
- ATP citrate lyase citrate-binding
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- CoA-ligase
- CS_ACL-C_CCL
- ATP citrate synthase
Pathways
Biological processes and signaling networks where the ACLY gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- organismal death
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- disorder of lipid metabolism
- heterozygous sporadic hypercholesterolemia
- heterozygous familial hypercholesterolemia
- neoplastic cell transformation
role in cell
- expression in
- formation
- formation in
- proliferation
- incorporation in
- synthesis in
- apoptosis
- production in
- survival
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- ficolin-1-rich granule lumen
- azurophil granule lumen
- Extracellular Space
- cell cortex
- Nucleus
- basal bodies
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACLY gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oxaloacetate metabolic process
- acetyl-CoA biosynthetic process
- citrate metabolic process
- cholesterol biosynthetic process
- lipid biosynthetic process
- coenzyme A metabolic process
- fatty acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- cytosol
- extracellular region
- azurophil granule lumen
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- ATP citrate synthase activity
- metal ion binding