Dglucy Gene Summary [Mouse]

Enables D-glutamate cyclase activity. Involved in glutamate metabolic process. Located in mitochondrial matrix. Is expressed in several structures, including adipose tissue; heart; liver; lung; and spleen. Orthologous to human DGLUCY (D-glutamate cyclase). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Dglucy
Official Name
D-glutamate cyclase [Source:MGI Symbol;Acc:MGI:2444813]
Ensembl ID
ENSMUSG00000021185
Bio databases IDs NCBI: 217830 Ensembl: ENSMUSG00000021185
Aliases D-glutamate cyclase
Synonyms 9030617O03Rik, C14orf159, D-glutamate cyclase, RGD1311756
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dglucy often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • D-glutamate cyclase
  • enzyme
  • protein binding
  • Domain of unknown function (DUF4392)

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
  • L-glutamic acid
regulated by
  • Immunoglobulin
  • tetradecanoylphorbol acetate
  • ETV6-RUNX1
  • Gstp1 (includes others)
  • KMT2A
disease
  • breast cancer
  • periodontal pocket
  • rectum cancer
phenotypes
  • increased glutamic acid level

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Mitochondria
  • mitochondrial matrix

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Dglucy gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • glutamate metabolic process

Cellular Component

Where in the cell the gene product is active
  • mitochondrial matrix

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • D-glutamate cyclase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.