Akr1c6 Gene Summary [Mouse]
Enables aldo-keto reductase (NADPH) activity and estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Involved in steroid biosynthetic process. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and steroid metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; liver and biliary system; lung; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; alcohol dependence; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C3 (aldo-keto reductase family 1 member C3); and AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akr1c6 |
| Official Name | aldo-keto reductase family 1, member C6 [Source:MGI Symbol;Acc:MGI:1933427] |
| Ensembl ID | ENSMUSG00000021210 |
| Bio databases IDs | |
| Aliases | aldo-keto reductase family 1, member C6 |
| Synonyms | 17beta-HSD-5, 20 α-HSD, 20 α SDH, 3alpha-HSD, Akr1c1, aldo-keto reductase family 1, member C1, aldo-keto reductase family 1, member C6, Hsd17b5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akr1c6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3(or 17)beta-hydroxysteroid dehydrogenase
- estradiol 17beta-dehydrogenase
- cortisone beta-reductase
- Aldo-keto reductase (AKR) superfamily
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- retinal dehydrogenase
- 3(or 17)alpha-hydroxysteroid dehydrogenase
- enzyme
- ketosteroid monooxygenase
- 15-hydroxyprostaglandin-D dehydrogenase (NADP)
- binding protein
- 20alpha-hydroxysteroid dehydrogenase
- aldo-keto reductase
- chlordecone reductase
- testosterone 17beta-dehydrogenase (NADP)
- ketoreductase
- Aldo/keto reductase family
- retinol dehydrogenase
- 3alpha-hydroxysteroid dehydrogenase (B-specific)
- geranylgeranyl reductase
- aldehyde reductase
- NADH or NADPH:quinone oxidoreductase
Pathways
Biological processes and signaling networks where the Akr1c6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol