Acox1 Gene Summary [Mouse]
This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | Acox1 |
| Official Name | acyl-Coenzyme A oxidase 1, palmitoyl [Source:MGI Symbol;Acc:MGI:1330812] |
| Ensembl ID | ENSMUSG00000020777 |
| Bio databases IDs | |
| Aliases | acyl-Coenzyme A oxidase 1, palmitoyl |
| Synonyms | ACO, Aco1 alpha, Aco1 α, aCoA, ACOX, Acyl-CoA Oxidase, Acyl-Co-A oxidase 1, acyl-Coenzyme A oxidase 1, palmitoyl, AOX, Aox subunit a, D130055E20RIK, Faoxase, fatty acyl-CoA oxidase, LOC100910385, MITCH, Palcoa, PALMCOX, Palmitoyl-CoA Oxidase, Pao, Paox, Peroxisomal Acyl-coA Oxidase, Peroxisomal Fatty Acyl-CoA Oxidase, Peroxisomal palmitoyl-Coa oxidase, Peroxysomal Acyl-coa Oxidase, RATACOA1, SCOX |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acox1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acyl-CoA oxidase
- FAD binding
- flavin adenine dinucleotide binding
- acyl-CoA dehydrogenase
- fatty acid binding
- Acyl-CoA dehydrogenase, middle domain
- Acyl-coenzyme A oxidase N-terminal
- protein homodimerization
- enzyme
- protein binding
- palmitoyl-CoA oxidase
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the Acox1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- liver cancer
- liver neoplasia
- renal clear cell adenocarcinoma
- peroxisomal acyl CoA oxidase deficiency
- organismal death
- microvesicular hepatic steatosis
- neoplastic cell transformation
role in cell
- quantity
- production in
- phosphorylation in
- proliferation
- transformation
- injury
- membrane proliferation
- adipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- cytosol
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acox1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- fatty acid catabolic process
- fatty acid beta-oxidation using acyl-CoA oxidase
- fatty acid oxidation
- spermatogenesis
- lipid homeostasis
- lipid metabolic process
- prostaglandin metabolic process
- very long-chain fatty acid metabolic process
- hydrogen peroxide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- membrane
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- FAD binding
- acyl-CoA oxidase activity
- fatty acid binding
- protein homodimerization activity
- protein binding
- flavin adenine dinucleotide binding
- PDZ domain binding
- palmitoyl-CoA oxidase activity